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Ann Thorac Surg 1977;24:80-82
© 1977 The Society of Thoracic Surgeons

Articles

Acute Clonidine Withdrawal Syndrome Following Open-Heart Operation

William I. Brenner, M.D., Abraham N. Lieberman, M.D.*

From the Departments of Cardiovascular Surgery and Neurology, New York University School of Medicine, New York, NY

Accepted for publication November 2, 1976.

* Address reprint requests to Dr. Lieberman, Associate Professor of Neurology, NYU School of Medicine, 566 First Ave, New York, NY 10016

A patient who underwent cardiopulmonary bypass developed a syndrome of malignant hypertension with agitated delirium, unresponsive to antihypertensive agents, following abrupt withdrawal of clonidine. The literature on this syndrome is reviewed with emphasis placed on prompt recognition. The syndrome can be reversed by resumption of clonidine administration and can be prevented by maintenance of clonidine levels through the perioperative period.






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