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Ann Thorac Surg 1977;24:59-61
© 1977 The Society of Thoracic Surgeons
From the Departments of Anesthesiology and Surgery, Indiana University School of Medicine, Indianapolis, IN
Accepted for publication December 13, 1976.
* Address reprint requests to Dr. Stoelting, Department of Anesthesiology, Indiana University School of Medicine, 1100 W Michigan St, Indianapolis, IN 46202
Vein graft flow (VGF) in response to peripheral venous administration of sodium nitroprusside (SNP) or diazepam was studied in 13 anesthetized patients following cardiopulmonary bypass for aortocoronary vein bypass graft operations. SNP (0.5 µg/kg/min) significantly reduced mean arterial pressure (p < 0.05). VGF paralleled the decreased blood pressure, but the reduction was not significant (p > 0.05). Diazepam (0.1 mg/kg) did not significantly alter blood pressure or VGF. We conclude that peripheral venous administration of SNP or diazepam is not a pharmacologically reliable method by which to increase VGF in the period immediately following a graft operation.
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