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The Annals of Thoracic Surgery, Vol 23, 520-528, Copyright © 1977 by The Society of Thoracic Surgeons

ARTICLES

Effects of conventional hypothermic ischemic arrest and pharmacological arrest on myocardial supply/demand balance during aortic cross-clamping

SM Goldstein, RL Nelson, DH McConnell and GD Buckberg

Aortic cross-clamping may produce ischemic damage due to a discrepancy between supply and demand. Supply is determined by noncoronary collateral flow and substrate stores, and demand by electromechanical activity, wall tension, and temperature. The effects of 60 minutes of conventional hypothermic ischemic arrest were compared to those of pharmacological arrest. Noncoronary collateral blood supply was comparable in both groups during cross-clamping. With ischemic arest, mechanical activity and endocardial electrical activity persisted and wall tension fell progressively. With pharmacological arrest, electromechanical activity stopped in less than 1 minute but returned (with increased wall tension) nearly 1 hour. Thirty minutes following reperfusion, coronary flow was redistributed away from subendocardium after ischemic arrest and toward endocardium after pharmacological arrest. Myocardial performance was depressed severely after conventional arrest and only mildy after pharmacological arrest. We conclude that aortic cross-clamping is safer with pharmacological arrest than with ischemic arrest. The cardioplegic solution modifies the supply/demand balance favorably, but it is washed out by noncoronary collateral blood supply.


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I. G. Duarte, S. T. Shearer, M. J. MacDonald, J. P. Gott, W. M. Brown III, J. Vinten-Johansen, and R. A. Guyton
Myocardial Distribution of Antegrade Cold Crystalloid and Tepid Blood Cardioplegia
Ann. Thorac. Surg., June 1, 1998; 65(6): 1610 - 1616.
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Copyright © 1977 by The Society of Thoracic Surgeons.