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Ann Thorac Surg 1977;23:374-375
© 1977 The Society of Thoracic Surgeons

Articles

Hemolysis due to Chemical Contamination of Clinical Perfusion Apparatus

Douglas F. Larson, M.S.*, Bruce Mayall, M.S., Robert M. Anderson, M.D.

Department of Surgery, University of Arizona College of Medicine, Tucson, AZ.

Accepted for publication August 11, 1976.

* Address reprint requests to Mr. Larson, Department of Surgery, University of Arizona College of Medicine, Tucson, AZ 85724.

A chemical contaminant found on the interior surface of the extracorporeal apparatus manufactured by the William Harvey Corporation was believed to have caused severe hematuria in 2 children. The biological activity of the contaminant was tested by mixing 50 ml of whole blood in contaminated cardiotomies; after 5 minutes of exposure lysis of one-sixth of the red blood cells was found. This hemolytic agent was concluded to be bisphenol A dissolved in an organic solvent, but the mechanism of contamination was never found.




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