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The Annals of Thoracic Surgery, Vol 23, 361-363, Copyright © 1977 by The Society of Thoracic Surgeons
G Merin, D Bitran, G Uretzky, E Superstine, S Cotev and JB Borman
The hemodynamic effects of dopamine were studied in 19 patients following
intracardiac operation or myocardial revascularization using extracorporeal
circulation. The heart rate, mean blood pressure, central venous pressure,
left atrial and pulmonary artery pressures, cardiac output, and urine
output were recorded before and at the end of one-hour infusions of
dopamine at 5, 10, and 15 mug/kg/min. Infusion of 5 mug/kg/min of dopamine
resulted in the highest gain in cardiac output and stroke work without an
increase in myocardial oxygen consumption, as evidenced by lack of
significant rise in heart rate. In addition, this dosage was not
accompanied by an increase in pulmonary or systemic vascular resistance,
nor were other untoward effects observed after administration of 5
mug/kg/min of dopamine.
ARTICLES
The hemodynamic effects of dopamine following cardiopulmonary bypass
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