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The Annals of Thoracic Surgery, Vol 23, 361-363, Copyright © 1977 by The Society of Thoracic Surgeons


ARTICLES

The hemodynamic effects of dopamine following cardiopulmonary bypass

G Merin, D Bitran, G Uretzky, E Superstine, S Cotev and JB Borman

The hemodynamic effects of dopamine were studied in 19 patients following intracardiac operation or myocardial revascularization using extracorporeal circulation. The heart rate, mean blood pressure, central venous pressure, left atrial and pulmonary artery pressures, cardiac output, and urine output were recorded before and at the end of one-hour infusions of dopamine at 5, 10, and 15 mug/kg/min. Infusion of 5 mug/kg/min of dopamine resulted in the highest gain in cardiac output and stroke work without an increase in myocardial oxygen consumption, as evidenced by lack of significant rise in heart rate. In addition, this dosage was not accompanied by an increase in pulmonary or systemic vascular resistance, nor were other untoward effects observed after administration of 5 mug/kg/min of dopamine.


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J Am Coll CardiolHome page
J. Li, G. Zhang, H. Holtby, T. Humpl, C. A. Caldarone, G. S. Van Arsdell, and A. N. Redington
Adverse Effects of Dopamine on Systemic Hemodynamic Status and Oxygen Transport in Neonates After the Norwood Procedure
J. Am. Coll. Cardiol., November 7, 2006; 48(9): 1859 - 1864.
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Copyright © 1977 by The Society of Thoracic Surgeons.