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Ann Thorac Surg 1977;23:361-363
© 1977 The Society of Thoracic Surgeons

Articles

The Hemodynamic Effects of Dopamine Following Cardiopulmonary Bypass

G. Merin, M.D.*, D. Bitran, M.D., G. Uretzky, M.D., E. Superstine, Ph.D., S. Cotev, M.D., J.B. Borman, Ch.B.

Department of Cardiothoracic Surgery, Division of Pharmacy Services, and Department of Anesthesiology, Hadassah University Hospital, Jerusalem, Israel

Accepted for publication September 7, 1976.

* Address reprint requests to Dr. Merin, Department of Cardiothoracic Surgery, Hadassah University Hospital, PO Box 499, Jerusalem, Israel.

The hemodynamic effects of dopamine were studied in 19 patients following intracardiac operation or myocardial revascularization using extracorporeal circulation. The heart rate, mean blood pressure, central venous pressure, left atrial and pulmonary artery pressures, cardiac output, and urine output were recorded before and at the end of one-hour infusions of dopamine at 5,10, and 15 µg/ kg/min. Infusion of 5µg/kg/min of dopamine resulted in the highest gain in cardiac output and stroke work without an increase in myocardial oxygen consumption, as evidenced by lack of significant rise in heart rate. In addition, this dosage was not accompanied by an increase in pulmonary or systemic vascular resistance, nor were other untoward effects observed after administration of 5 µg/kg/min of dopamine.




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