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The Annals of Thoracic Surgery, Vol 23, 348-352, Copyright © 1977 by The Society of Thoracic Surgeons

ARTICLES

Contemporary management of myasthenia gravis: the clinical role of thymectomy

SL Faulkner, A Ehyai, RD Fisher, GM Fenichel and HW Bender Jr

Thirty-six patients with myasthenia gravis have been evaluated and treated over the past five years. Eleven patients had ocular myasthenia gravis and responded well to anticholinesterase medications. Twenty- five patients had generalized myasthenia gravis, and 22 of them were initially treated with anticholinesterase medications; 18(82%) failed to improve or to maintain an initial improvement on medication, and 14 of these 18 patients underwent thymectomy. In addition, 3 patients underwent thymectomy as part of their initial treatment during the later part of this study. All thymectomies were performed through a median sternotomy. All 17 patients manifested sustained improvement as judged by a gain in strength and decrease in medications. Thymectomy is beneficial in the treatment of myasthenia gravis, and it is most efficacious when performed early in the course of the disease.




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Copyright © 1977 by The Society of Thoracic Surgeons.