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Ann Thorac Surg 1977;23:342-347
© 1977 The Society of Thoracic Surgeons

Articles

Transcervical Thymectomy with the Aid of Mediastinoscopy for Myasthenia Gravis: Eight Years' Experience

Gudmund Klingen, M.D.*, Lennart Johansson, M.D., Carl-Johan Westerholm, M.D., Christer Sundstrom, M.D.

Department of Thoracic Surgery, University Hospital, and the Department of Pathology, University of Uppsala School of Medicine, Uppsala, Sweden

Accepted for publication November 11, 1976.

* Address reprint requests to Dr. Klingen, Department of Thoracic and Cardiovascular Surgery, University Hospital, S-750 14 Uppsala 14, Sweden.

Fifty-eight patients with myasthenia gravis, including 12 children, underwent thymectomy. Eleven of them (19%) had total stable remission and 42 (72%) showed clinical improvement and were able to reduce their anticholinesterase medication. These two groups combined comprised 53 patients (91%). There was no operative or postoperative mortality.

Histopathological examination of the resected thymuses revealed a tumor (benign thymoma) in 4 patients (7%), thymitis in 36 (62%), and no pathological changes in 18 (31%). Patients with few or no germinal centers tended to achieve remission more rapidly than those with numerous germinal centers.




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