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Ann Thorac Surg 1977;23:337-341
© 1977 The Society of Thoracic Surgeons

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Articles

Cardiac Valve Prostheses, Anticoagulation, and Pregnancy

Department of Surgery, Montreal Heart Institute, Montreal, Que, Canada

Accepted for publication August 30, 1976.

^* Address reprint requests to Dr. Claude M. Grondin, Montreal Heart Institute, 5000 E Belanger St, Montreal HIT 1C8, Que, Canada.

A series is presented of 7 women who underwent cardiac valve replacement and who ultimately became pregnant. The only infant death was that of a premature baby whose mother received oral anticoagulants until delivery. The remaining 6 babies were normal and survived. One mother died suddenly on the fourth postpartum day and was found to have a periprosthetic clot on postmortem examination.

Although a certain risk exists for the fetus whose mother receives oral anticoagulants since they cross the placental barrier, this risk is far lower than that for the mother who does not receive anticoagulation. From a prospective point of view, it would appear preferable to use prostheses such as the porcine heterograft that do not necessitate the administration of anticoagulants.

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