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Ann Thorac Surg 1977;23:333-336
© 1977 The Society of Thoracic Surgeons

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Articles

Cephalothin Prophylaxis and Valve Replacement

Departments of Cardiovascular Surgery and Medicine, Victoria Hospital, and the School of Medicine, University of Western Ontario, London, Ont, Canada

Accepted for publication August 10, 1976.

^* Address reprint requests to Dr. Austin, Department of Medicine, Victoria Hospital, London, Ont, CanadaN6A4G5.

In a study of antibiotic prophylaxis in adults undergoing heart valve replacement, we found that a 2 gm dose of cephalothin given intraoperatively produced adequate antimicrobial activity in the bloodstream throughout the period of cardiopulmonary bypass. A dosage of 1 gm every four hours postoperatively did not lead to significant accumulation of the antibiotic.

With prophylaxis restricted to the intraoperative and early postoperative period, adverse drug reactions and superinfections were not a problem. Further, no cases of prosthetic valvulitis were encountered.

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