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The Annals of Thoracic Surgery, Vol 23, 163-166, Copyright © 1977 by The Society of Thoracic Surgeons

ARTICLES

Candida albicans infection of sternum and costal cartilages: combined operative treatment and drug therapy and 5-fluorocytosine

FE Thomas Jr, CE Martin, RD Fisher and RH Alford

Two patients with candidal sternal osteomyelitis have been successfully treated by operative debridement and adjuvant drug therapy with 5- fluorocytosine. One patient had developed postoperative candidal wound infection after sternotomy, and the other acquired candidal sternal osteomyelitis following Candida fungemia. The diagnosis, suggested by culture, was confirmed by identification of Candida pseudohyphae in debrided tissue. Histological confirmation of candidal sternal osteomyelitis indicates the need for operative debridement and specific systemic antifungal therapy. The drug 5-fluorocytosine appears to provide effective oral therapy in this situation.




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Copyright © 1977 by The Society of Thoracic Surgeons.