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The Annals of Thoracic Surgery, Vol 23, 14-19, Copyright © 1977 by The Society of Thoracic Surgeons

ARTICLES

Can the frequency of myocardial infarction be reduced during coronary artery operations

JF Ray 3d, DA Tewksbury, WO Myers, FJ Wenzel and RD Sautter

A prospective experiment was carried out in 56 patients undergoing coronary artery revascularization to determine whether those having a glucose-insulin-potassium (GIK) perfusion during the procedure would have fewer myocardial infarctions (MI) compared with patients given a control perfusion of Normosol-R. Six patients (11%) developed an MI, defined as a 24-hour creatine phosphokinase MB isoenzyme value of 100 IU per liter or greater. Four (13%) had control perfusions and 2(8%) had GIK perfusion. One MI in a double-graft recipient who had GIK perfusion occurred because of a technical surgical error; therefore, the corrected MI rate was 13% in control patients compared with 4% for the GIK group. These data, as well as the more frequent spontaneous defibrillation in patients who had GIK perfusion, suggest that GIK was of benefit.


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Home page
 Ann. Thorac. Surg.Home page
W. Bothe, M. Olschewski, F. Beyersdorf, and T. Doenst
Glucose-Insulin-Potassium in Cardiac Surgery: A Meta-Analysis
Ann. Thorac. Surg., November 1, 2004; 78(5): 1650 - 1657.
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Copyright © 1977 by The Society of Thoracic Surgeons.