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Ann Thorac Surg 1976;22:429-435
© 1976 The Society of Thoracic Surgeons

Articles

Effects of Morphine and Halothane Anesthesia on Coronary Blood Flow

Frederick L. Grover, M.D.*, George E. Webb, M.D., Victor Bevis, M.D., John G. Fewel, B.A.

From the Division of Cardiothoracic Surgery and the Department of Anesthesiology, The University of Texas Health Science Center at San Antonio, and the Audie L. Murphy Veterans Administration Hospital, San Antonio, TX

* Address reprint requests to Dr. Grover, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, San Antonio, TX 78284

This study was undertaken to determine the relative effects of morphine and halothane anesthesia on coronary blood flow. Right heart bypass was instituted in 20 dogs by draining the vena cava blood into a cardiotomy reservoir and returning it to the main pulmonary artery. Coronary sinus drainage was measured by a right ventricular cannula. Group I (10 dogs) was sequentially given 0.5, 1, 1.5, 2.0, and 2.5% halothane. Group II (10 dogs) was given 1, 2, 3, 4, and 5 mg per kilogram of morphine intravenously. Arterial pressure, coronary sinus blood flow, cardiac output, arterial pH, PCO 2, and PO 2 were determined and repeated at each dose level of anesthesia and compared to the control values.

Morphine significantly increased coronary flow at 3, 4, and 5 mg/kg without pressure adjustment and at 2 mg/kg after pressure adjustment. Coronary flow with halothane was unchanged from control values except for a decrease at 2.5%. Coronary flow was significantly greater with 3, 4, and 5 mg/kg of morphine than with 1.0 and 1.5% halothane.






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Copyright © 1976 by The Society of Thoracic Surgeons.