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Ann Thorac Surg 1976;22:322-329
© 1976 The Society of Thoracic Surgeons

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Articles

Retrograde Venous Cardiac Perfusion for Myocardial Revascularization

An Experimental Evaluation

Department of Surgery, University of Arkansas for Medical Sciences, Little Rock, AR.

^* Address reprint requests to Dr. Williams, Department of Surgery, University of Arkansas for Medical Sciences, 4301 W Markham, Little Rock, AR 72201.

This study evaluates cardiac function in dogs during retrograde perfusion through the coronary sinus. Five hearts perfused retrograde in an ex vivo apparatus demonstrated rapid and marked increases in weight and perfusion pressure, became hemorrhagic, and contracted poorly within one hour. Five similarly perfused hearts treated with phenoxybenzamine experienced no increase in weight or perfusion pressure and maintained good color and contractions for up to one hour. Five additional hearts treated with phenoxybenzamine did not develop hemorrhage, edema, increased weight, or increased perfusion pressure but could maintain the systemic circulation for only brief periods after 15 minutes of intermittent cardiopulmonary bypass support.

We conclude that cardiac viability can be maintained with retrograde perfusion enhanced with alpha blocking agents. However, hearts so perfused cannot maintain adequate systemic pressure. The data suggest that extensive myocardial revascularization through the retrograde venous route would be ineffective.

This article has been cited by other articles:

				M. S. Hochberg and W. G. Austen Selective Retrograde Coronary Venous Perfusion Ann. Thorac. Surg., June 1, 1980; 29(6): 578 - 588. [Abstract] [PDF]

				R. J. Bates, M. Toscano, S. C. Balderman, and C. E. Anagnostopoulos The Cardiac Veins and Retrograde Coronary Venous Perfusion Ann. Thorac. Surg., January 1, 1977; 23(1): 83 - 90. [Abstract] [PDF]