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David B. Skinner
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Ann Thorac Surg 1976;21:462-469
© 1976 The Society of Thoracic Surgeons

Articles

Immunology and Thoracic Surgery

David B. Skinner, M.D.*, Tom R. DeMeester, M.D.

From The Department of Surgery, University of Chicago Pritzker School of Medicine, Chicago, IL.

* Address reprint requests to Dr. Skinner, Department of Surgery, University of Chicago Pritzker School of Medicine, 950 E 59th St, Chicago, IL 60637.

This report reviews the current status of three types of diseases in which knowledge of immunology is changing the practice of thoracic surgery. Evidence is presented for myasthenia gravis being an autoimmune disease. Thymectomy is widely considered to be the therapy of choice for patients with generalized myasthenia regardless of age or sex. Opportunistic pulmonary infections of unusual types are being encountered frequently in patients receiving immunosuppressive drugs for organ transplantation or malignancy. The important role of bronchial brushing and open lung biopsy is stressed. Immunotherapy of several types is currently being investigated experimentally and clinically and promises to change therapy for bronchogenic and esophageal neoplasms.






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Copyright © 1976 by The Society of Thoracic Surgeons.