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Ann Thorac Surg 1976;21:250-258
© 1976 The Society of Thoracic Surgeons

Articles

Immunology and Lung Cancer

E. Carmack Holmes, M.D.*

From the Division of Oncology and the Division of Thoracic Surgery, Department of Surgery, UCLA School of Medicine, Los Angeles, and the Surgical Services, Sepulveda Veterans Administration Hospital, Sepulveda, CA.

* Address reprint requests to Dr. Holmes, Division of Oncology, 54-140, UCLA School of Medicine, Los Angeles, CA 90024

Carcinoma of the lung is the number one cancer killer in the United States. The overall cure rate is about 10%, and although resection is the best treatment available, five-year survival following operation is only 25%. Recent studies have shown that patients with lung cancer are immunosuppressed but that pulmonary tumors do contain tumor-associated antigens. Studies of other human tumors indicate that immunotherapy can augment tumor immunity and can be an effective surgical adjuvant.

This communication reviews the basic principles of tumor immunology, with emphasis on the immunology of lung cancer, and discusses how these principles may be applied to the therapy of lung cancer.






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