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Ann Thorac Surg 1976;21:158-163
© 1976 The Society of Thoracic Surgeons

Articles

The Effect of Simultaneous Administration of Levarterenol and Phentolamine on Renal Blood Flow

Vincent M. Cimmino, M.D., Edward L. Bove, M.D., Louis C. Argenta, M.D., John W. Brown, M.D., Marvin M. Kirsh, M.D.*

From the Department of Surgery, Section of Thoracic Surgery, University of Michigan Medical Center, Ann Arbor, MI.

Accepted for publication March 11, 1975.

* Address reprint requests to Dr. Kirsh, Section of Thoracic Surgery, University of Michigan Medical Center, Ann Arbor, MI 48109

The effect of simultaneous administration of levarterenol and phentolamine upon renal blood flow was studied over a 3-hour period in 22 mongrel dogs. The infusion of levarterenol alone produced a fall in renal blood flow that ranged from 28 to 58% from the baseline value. When both drugs were administered simultaneously, renal flow fell only 17 to 22% from baseline (p < 0.05). From these studies we conclude that the simultaneous administration of levarterenol and phentolamine in optimal ratios maintains renal blood flow near baseline levels.




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[Abstract] [PDF]


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