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The Annals of Thoracic Surgery, Vol 21, 158-163, Copyright © 1976 by The Society of Thoracic Surgeons

ARTICLES

The effect of simultaneous administration of levarterenol and phentolamine on renal blood flow

VM Cimmino, EL Bove, LC Argenta, JW Brown and MM Kirsh

The effect of simultaneous administration of levarterenol and phentolamine upon renal blood flow was studied over a 3-hour period in 22 mongrel dogs. The infusion of levarterenol alone produced a fall in renal blood flow that ranged from 28 to 58% from the baseline value. When both drugs were administered simultaneously, renal flow fell only 17 to 22% from baseline (p less than 0.05). From these studies we conclude that the simultaneous administration of levarterenol and phentolamine in optimal ratios maintains renal blood flow near baseline levels.




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Copyright © 1976 by The Society of Thoracic Surgeons.