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Ann Thorac Surg 1976;21:38-42
© 1976 The Society of Thoracic Surgeons

Articles

Cerebrovascular Blockade Associated with Thoracotomy and Its Prevention with a Platelet Inhibitor

Russel H. Patterson, Jr., M.D.*

Department of Surgery, Division of Neurosurgery, Cornell University Medical College, New York, NY

Accepted for publication June 13, 1975.

* Address reprint requests to Dr. Patterson, Division of Neurosurgery, Cornell University Medical College, 1300 York Ave., New York, NY 10021

Dogs subjected to a thoracotomy in which a rib-spreading retractor was employed developed filling defects in the cerebral microcirculation attributable to obstruction by microemboli. These changes were not observed in control groups and could be prevented in the experimental group by pretreatment with RA233, a platelet inhibitor. It is possible that microembolic-related complications of operations and trauma, such as pulmonary insufficiency, might be ameliorated by the use of platelet inhibitors.






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Copyright © 1976 by The Society of Thoracic Surgeons.