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Parry B. Larsen
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Ann Thorac Surg 1976;21:16-18
© 1976 The Society of Thoracic Surgeons

Articles

Sodium Nitroprusside as a Coronary Vasodilator in Man

A Comparison of the Effects of Sodium Nitroprusside and Papaverine Hydrochloride on Aortocoronary Saphenous Vein Graft Flow

Parry B. Larsen, M.D.*, Billy K. Yeh, M.D., Ph.D., Thomas O. Gentsch, M.D., Ernest A. Traad, M.D., Anthony R. Faraldo, M.D., Arthur J. Gosselin, M.D., Paul S. Swaye, M.D.

Division of Clinical Investigation, Miami Heart Institute, Miami Beach, FL

Accepted for publication April 9, 1975.

* Address reprint requests to Dr. Larsen, Miami Heart Institute, Miami Beach, FL 33140

Blood flow in aortocoronary saphenous vein grafts was studied in response to intragraft injection of sodium nitroprusside and papaverine hydrochloride. Following injection of 50 µg of sodium nitroprusside, mean graft flow increased from 40.1 ± 4.5 to 81.3 ± 8.5 ml per minute. Administration of 30 mg of papaverine hydrochloride caused mean graft flow to rise from 35.4 ± 3.9 to 70 ± 7.9 ml per minute. Sodium nitroprusside increases aortocoronary graft flow, the doubling effect of 50 µg of the drug being of the same order of magnitude as that induced by 30 mg of papaverine hydrochloride.




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