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Ann Thorac Surg 1975;20:274-281
© 1975 The Society of Thoracic Surgeons

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Articles

Analysis of Homograft Valve Failure in 311 Patients Followed up to 10 Years

From the Cardiothoracic Institute and National Heart Hospital, London, England

^* Address reprint requests to Dr. Moore, 2900 North St., Beaumont, Tex. 77702

Homograft aortic valve replacement was performed in 311 patients at the National Heart Hospital, London, between 1964 and 1973. Valve failure has occurred in 61 patients (20%), 32 of whom survived reoperation. From 1963 through 1967, 156 valves were freeze-dried and account for 56 of the valve failures. From 1968 to 1973, 118 fresh or fresh-frozen valves resulted in only 5 failures. Six general types of failure have been identified: calcification (13), dehiscence (15), infective endocarditis (17), prolapse (6), cusp degeneration (5), and tear or perforation (5).

Valve failure may be due to surgical technical error resulting in dehiscence or valve incompetence, or it may be related to degenerative changes in the homograft. The clinical results, supported by gross and histological examination and viability testing, enable us to conclude that fresh or fresh-frozen valves are superior to freeze-dried valves, having resulted in only 4% valve failure over the past five years.

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