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Ann Thorac Surg 1975;20:7-10
© 1975 The Society of Thoracic Surgeons

Articles

Laboratory Evaluation of Intraoperative Myocardial Protection

The Need for Appropriate Animal Models

Bruce A. Reitz, M.D.*

From the Clinic of Surgery, National Heart and Lung Institute, National Institutes of Health, Bethesda, Md. Present address: Division of Cardiovascular Surgery, Stanford University Medical Center, Palo Alto, Calif. 94305.

* Address reprint requests to the Clinic of Surgery, National Heart and Lung Institute, National Institutes of Health, Bethesda, Md. 20014.

The investigative laboratory is the appropriate place to evaluate methods of intraoperative myocardial protection. It is becoming apparent that diseased myocardium is more susceptible to intraoperative injury than is normal heart muscle, and so animal models that simulate human cardiac disease states such as chronic left ventricular hypertrophy should be used to assess various techniques. Long-term studies on animals surviving operation are necessary in order to evaluate the chronic effects of various methods of protection.






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