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Ann Thorac Surg 1975;20:106-113
© 1975 The Society of Thoracic Surgeons

Articles

Postbypass Treatment

Harold Feinberg, Ph.D., Sidney Levitsky, M.D.*,*

From the Departments of Pharmacology and Surgery, School of Basic Medical Science and Abraham Lincoln School of Medicine of the University of Illinois College of Medicine, Chicago, Ill.

* Address reprint requests to Dr. Levitsky, Department of Surgery, Abraham Lincoln School of Medicine of the University of Illinois College of Medicine, P.O. Box 6998, Chicago, Ill. 60680.

Ischemia induced by cross-clamping the aorta during open-heart operations initiates progressive metabolic derangement. If the duration of ischemia is short, these derangements are easily reversed by restoring the flow of blood containing oxygen and substrate. If ischemia is prolonged, treatment designed to ameliorate ischemic damage may be necessary. Three problems are discussed: (1) loss of adenine nucleotides, particularly adenosine triphosphate, (2) impairment of calcium sequestration, and (3) formation of microemboli in coronary vessels. The rationale for postbypass treatment is presented.






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Copyright © 1975 by The Society of Thoracic Surgeons.