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Ann Thorac Surg 1975;20:101-105
© 1975 The Society of Thoracic Surgeons

Articles

Prevention of Intraoperative Myocardial Injury by Pretreatment with Pharmacological Agents

Paul A. Hickey, M.D.

From the Clinic of Surgery, National Heart and Lung Institute, National Institutes of Health, Bethesda, Md. 20014.

Pharmacological agents administered prior to the institution of myocardial anoxia or ischemia may protect the myocardium by preventing ATP depletion, structural damage to cell membranes and organelles, and postanoxic disturbances in coronary microcirculation. Propranolol, dipyridamole, nitroglycerin, and mannitol all have the potential to protect the myocardium in one or more of these ways and thus have promise for clinical use.






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Copyright © 1975 by The Society of Thoracic Surgeons.