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Ann Thorac Surg 1975;19:670-676
© 1975 The Society of Thoracic Surgeons

Articles

Prophylactic Antibiotics in Noncardiac Thoracic Operations

Lester R. Bryant, M.D.*, Marcus L. Dillon, M.D., Kazi Mobin-Uddin, M.D.

From the Departments of Surgery, University of Kentucky Medical Center, Lexington, Ky., and Louisiana State University Medical Center, New Orleans, La.

* Address reprint requests to Dr. Bryant, Section of Thoracic and Cardiovascular Surgery, LSU Medical Center, 1542 Tulane Ave., New Orleans, La. 70112.

A high incidence of thoracotomy wound infection and empyema in 1972 was associated with inadequate and irregular administration of prophylactic antibiotics. Beginning with 1973, a strict regimen was adopted that combined systemic cephalosporins and two topical antibiotics (cephalothin and kanamycin). Emphasis was placed on preoperative administration of the systemic agent and on use of the topical drugs before the operative field was contaminated.

The patient groups for 1972 and 1973 were similar in most respects, but the wound complication rate was 18.4% in 1972 and 4.8% in 1973.




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