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Ann Thorac Surg 1975;19:639-647
© 1975 The Society of Thoracic Surgeons

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Articles

Functional Changes in Platelets During Extracorporeal Circulation

From the Departments of Surgery and Medicine, Mt. Sinai School of Medicine, New York, and North Shore University Hospital–Cornell University Medical College, Manhasset, and the Department of Surgery, Bronx Veterans Administration Hospital, Bronx, N.Y.

Accepted for publication January 14, 1975.

^* Address reprint requests to Mr. Tamari, Coordinator of Biomedical Engineering, North Shore University Hospital, 300 Community Dr., Manhasset, N.Y. 11030.

An in vitro trauma test was conducted to determine the effects of extracorporeal circulation on platelet count and function. Fresh human blood was circulated in two identical in vitro circuits for six hours at a rate of 500 ml per minute (500 recirculations). One circuit included a G.E. – Peirce membrane lung and the other was a control. Platelet aggregation induced by adenosine diphosphate (ADP), epinephrine, or collagen was studied before and after six hours of perfusion. No important drop in platelet count occurred in the control circuit (Control-C) following bypass, but there was a 20% drop for the lung circuit (Lung-C). Platelet aggregation was reduced by about 30% for the control circuit and 65% for the lung circuit. The large decrease in platelet function accompanied by only a moderate decrease in platelet count is discussed in terms of loss of the youngest and most active platelets, platelet inhibition due to ADP released by red blood cell lysis, and platelet trauma.

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