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The Annals of Thoracic Surgery, Vol 19, 406-414, Copyright © 1975 by The Society of Thoracic Surgeons

ARTICLES

Biochemical modifications of fascia lata for autologous valve replacement

B Bharadwaj, E Kurylo and WW Kay

The biochemistry of canine fascia lata was studied to assess the feasibility of tissue modification with a variety of cross-linking reagents and growth inhibitors in order to provide a more suitable material for heart valves. Chemical determinants for maximal reactivity were consequently established for several growth inhibitors, of which the hydrophobic ligands difluorodinitrobenzene, octadecylamine, and oleylamine were the most effective in preventing invasive cellular growth. This enhanced the longevity of atrial grafts in dogs as judged from morphological and histological examination of excised grafts.




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Copyright © 1975 by The Society of Thoracic Surgeons.