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Ann Thorac Surg 1975;19:406-414
© 1975 The Society of Thoracic Surgeons

Articles

Biochemical Modifications of Fascia Lata for Autologous Valve Replacement

B. Bharadwaj, M.D.*, E. Kurylo, B.Sc., W.W. Kay, Ph.D.

From the Department of Surgery, University Hospital, Saskatoon, Sask., Canada.

Accepted for publication October 18, 1974.

* Address reprint requests to Dr. Bharadwaj, Department of Surgery, University Hospital, Saskatoon, Sask., Canada.

The biochemistry of canine fascia lata was studied to assess the feasibility of tissue modification with a variety of cross-linking reagents and growth inhibitors in order to provide a more suitable material for heart valves. Chemical determinants for maximal reactivity were consequently established for several growth inhibitors, of which the hydrophobic ligands difluorodinit-robenzene, octadecylamine, and oleylamine were the most effective in preventing invasive cellular growth. This enhanced the longevity of atrial grafts in dogs as judged from morphological and histological examination of excised grafts.






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