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Ann Thorac Surg 1975;19:309-312
© 1975 The Society of Thoracic Surgeons

Articles

A Simple Model of the Hemodynamic Effects of a Proximal Coronary Artery Narrowing

Edward H. Klopp, M.D., Vincent L. Gott, M.D.*

Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, Md

Accepted for publication October 14, 1974.

* Address reprint requests to Dr. Gott, Blalock 608, The Johns Hopkins Hospital, Baltimore, Md. 21205

A simple mathematical model of the hemodynamic effects of a discrete proximal coronary artery obstruction is presented. The model demonstrates that resting myocardial flow demands fail to be met when the vessel diameter is decreased by 75% or greater. More strikingly, it shows that the maximum flow obtainable for increased myocardial oxygen demand begins to fall significantly with a lesion causing a 40 to 50% obstruction. The implications of these findings in relation to stress-induced angina are discussed.






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