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The Annals of Thoracic Surgery, Vol 19, 309-312, Copyright © 1975 by The Society of Thoracic Surgeons

ARTICLES

A simple model of the hemodynamic effects of a proximal coronary artery narrowing

EH Klopp and VL Gott

A simple mathematical model of the hemodynamic effects of a discrete proximal coronary artery obstruction is presented. The model demonstrates that resting myocardial flow demands fail to be met when the vessel diameter is decreased by 75% or greater. More strikingly, it shows that the maximum flow obtainable for increased myocardial oxygen demand begins to fall significantly with a lesion causing a 40 to 50% obstruction. The implications of these findings in relation to stress- induced angina are discussed.




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Copyright © 1975 by The Society of Thoracic Surgeons.