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Ann Thorac Surg 1975;19:301-308
© 1975 The Society of Thoracic Surgeons

Articles

Effects of an Abdominal Left Ventricular Assist Device on Myocardial Oxygen Supply/Demand Ratios in Normally Perfused and Ischemic Bovine Myocardium

David A. Hughes, M.D., Stephen R. Igo, Benedict D.T. Daly, M.D., Joseph J. Migliore, M.D., John C. Norman, M.D.*

Cardiovascular Surgical Research Laboratories, Texas Heart Institute of St. Luke's Episcopal and Texas Children's Hospitals, Texas Medical Center, Houston, Tex

Accepted for publication October 16, 1974.

* Address reprint requests to Dr. Norman, P.O. Box 20269, Texas Heart Institute, Houston, Tex. 77025

The effects of an abdominal left ventricular assist device (ALVAD) on subendocardial oxygen supply/demand ratios as reflected by diastolic pressure-time index/tension-time index (DPTI/TTI) were investigated in calves. Control DPTI/TTI ratios were 1.09 ± 0.12 (mean ± SD). With ALVAD actuation the ratios increased to 5.73 ± 3.2. Following circumflex coronary artery occlusion, control ratios decreased to 0.04 ± 0.05 in the ischemic area and 0.97 ± 0.20 in the nonischemic areas. With ALVAD actuation in the presence of circumflex occlusion, the depressed ratios were increased to 1.37 ± 0.39 in the ischemic zone and 9.71 ± 2.5 in the nonoccluded segments. Subendocardial oxygen supply/demand ratios were significantly improved by ALVAD assistance following induced subendocardial ischemia.




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J Biomater Appl, January 1, 1986; 1(1): 39 - 105.
[Abstract] [PDF]


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