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Ann Thorac Surg 1975;19:158-169
© 1975 The Society of Thoracic Surgeons

Articles

The Fate of Autologous Fascia Lata Grafts in Dogs

B. Bharadwaj, M.D.*, E. Kurylo, B.Sc., W.W. Kay, Ph.D.

From the Department of Surgery, University Hospital, University of Saskatchewan, Saskatoon, Sask., Canada.

Accepted for publication September 18, 1974.

* Address reprint requests to Dr. Bharadwaj, Department of Surgery, University Hospital, Saskatoon, Sask., Canada.

The fate of tricuspid fascia lata valves and intracardiac grafts was studied morphologically, histologically, and biochemically in dogs. Severe degenerative changes occurring by 21 days were largely correlated with graft thickening due to gross endothelialization. A primary event in graft alteration was an initial loss of the indigenous fibroblast population as detected both microscopically and by autoradiography after pulse labeling with 14C-N-ethylmaleimide. Using different isotopic labeling procedures, both the in vivo and in vitro graft degradation patterns demonstrated that a second early event in graft degeneration is surface collagen solubilization. Further progressive graft degradation was correlated in vivo with endothelialization and collagenase secretion by invasive cells.




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B. Bharadwaj, E. Kurylo, and W. W. Kay
Biochemical Modifications of Fascia Lata for Autologous Valve Replacement
Ann. Thorac. Surg., April 1, 1975; 19(4): 406 - 414.
[Abstract] [PDF]


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