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Ann Thorac Surg 1974;18:494-503
© 1974 The Society of Thoracic Surgeons

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Articles

Oxygen Utilization During Surface-Induced Deep Hypothermia

Departments of Surgery and Anesthesiology, University of Washington School of Medicine, Seattle, Wash

Accepted for publication May 9, 1974.

^** Address reprint requests to Dr. Mohri, Department of Surgery, University of Washington School of Medicine, Seattle, Wash. 98195

Oxygen utilization during surface-induced deep hypothermia under ether anesthesia and respiratory alkalosis, with and without 30 minutes of circulatory arrest, was studied in 12 dogs. Oxygen consumption and saturation, hemoglobin, hematocrit, Po₂, Pco₂, and pH of arterial and mixed venous blood were measured, and oxygen content, arteriovenous oxygen differences, and cardiac output were calculated.

There were slightly decreased but persistent arteriovenous oxygen differences during cooling until low cardiac output developed around 18°C., which would suggest continued unloading of oxygen from hemoglobin despite the presence of severe alkalosis. The oxygen debt developed during total circulatory occlusion or from low cardiac output was repaid in the early rewarming period when circulation was reestablished. Venous Po₂ became progressively lower below 25°C. Tissue oxygen uptake is presumably accomplished by lowering tissue oxygen tension, but this drop apparently does not grossly impair tissue function since all dogs tolerated the procedure well and are long-term survivors.

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